Inspiratory Efforts Achieved in Use of the Technosphere® Insulin Inhalation System

Objective: The Technosphere ® Insulin (TI) inhalation system comprises TI powder premetered into unit dose cartridges and the patient-friendly, reusable, breath-powered MedTone ® inhaler. This high-resistance system uses a patient’s inspiratory effort to effect TI powder de-agglomeration and promote subsequent deep-lung delivery. This study reports on flow and pressure data achieved by patients with diabetes using the MedTone system. Method: MedTone inhalers containing empty cartridges were adapted with pneumotach measuring devices to capture inhalation profiles. The measuring apparatuses had negligible impact on the nominal MedTone system resistance level of 0.117 kPa 0.5 /liters/min. Each of 56 subjects inhaled twice to mimic TI clinical study dosing instructions.