Management of Neonates Admitted with Tetralogy of Fallot: Changing Patterns Across the United States.

Abstract Background This study describes the evolving in-hospital management strategies for neonates who are diagnosed with Tetralogy of Fallot (ToF). Methods The Pediatric Health Information System (PHIS) database was used to identify admitted patients 0-1 month old with ToF from 2010-2019. Era 1: 2010-2014; Era 2: 2015-2019. ICD codes were used to identify related interventions, which occurred during this admission but not necessarily as a neonate: full repair, systemic-to-pulmonary shunt, and percutaneous stent in the RVOT &/or PDA. Results 6,021 neonates were diagnosed with ToF. 2,030(34%) of them underwent an intervention:60% had total repair, 31% systemic-to-pulmonary shunt, 9% percutaneous stent. In the no-intervention cohort, in-hospital mortality was 9%. In-hospital mortality between repair(6%), shunt(6%), and stent(3%) patients(p=0.446) did not differ. Regarding regional practices, no-intervention was most frequently employed in the Midwest (69%vs.65% average for all other regions(avg),p=0.075) while interventions overall were performed most frequently in the West (36%vs.33.5% avg, p=0.075). Amongst the interventions, full repair was most frequent in the Northeast (76%vs.57% avg,p Conclusions Although the majority of neonates admitted with ToF are discharged with no intervention, over 1/3 undergo some intervention with a 3-6% mortality. Though the proportion of these patients intervened upon is unchanged over the past decade, the types of intervention have changed and significant regional differences exist.