RELEVÂNCIA DE MODELOS EXPERIMENTAL PARA AVALIAÇÃO FUNCIONAL DA CREATININA

Creatinine is a substance resulting from degradation of phosphorylated creatine and is used as an important marker of renal function estimation. Experimental models have been increasingly used to predict the pathophysiology of disease in humans and intervention procedures to kidney disease by drugs or even prophylactic measures. So many studies involving toxicity of medicinal plants, existing drugs, some parasitic diseases, chronic diseases such as diabetes and others is related to changes in creatinine concentrations. In this sense this study aimed to conduct a literature review of the extensive use of quantification of creatinine in experimental models using mice. We discussed articles indexed in Pubmed in the period from 1 January 2013 to 01 January 2016. We showed a variety of models used to explore the metabolic pathways of creatine, which are raised in a variety of diseases that affect a variety organs and systems. Thus demonstrating that this parameter is also often reported, and that the models used must exhibit specificity and sensitivity for the desired inquiry.