Maintenance of early pregnancy without early hormone support after frozen-thawed embryo transfer in hormone replacement treatment cycles

Objective To report two successful pregnancies after frozen-thawed ET in discontinued hormone replacement treatment cycles. Design Case report. Setting University hospital. Patient(s) Two infertile patients. Intervention(s) Hormone replacement treatment for endometrial preparation and frozen-thawed ET. Main Outcome Measure(s) Ovarian ultrasonography, serial hormone measurements of serum E 2 and P, successful pregnancy, and follow-up visit. Result(s) One patient discontinued both E 2 and P support 2 weeks after ET. The other discontinued estrogen support on the day preceding ET. No spontaneous follicle development was observed by ultrasonography, and no increase in serum P concentration was observed. Both patients became pregnant and achieved deliveries. Conclusion(s) These two cases show that maintenance of pregnancy is possible without early hormone support in hormone replacement treatment cycles.