A Noncovalent Muscle-Inspired Hydrogel with Rapid Recovery and Anti-Fatigue Property Under Cyclic Stress

2019 
Designing muscle-inspired hydrogels that possess structure and bioactivity similar to muscles is an eternal pursuit in material sciences and tissue engineering. However, the development of a muscle-inspired hydrogel via the formation of noncovalent interactions remains challenging, and its application in sustained loading situations such as cyclic stresses is limited. Herein, H-bonds and microcrystalline domains were introduced, and a noncovalent muscle-inspired hydrogel was developed to mimic both the physical structure and functionality of muscles at the macroscopic level. The hydrogel exhibited excellent mechanical properties (a fracture strength of 2.16 ± 0.08 MPa, fracture strain of 830 ± 23%, elastic modulus of 275 ± 9 KPa, and toughness of 7.04 ± 0.80 MJ/m3), a large energy dissipation (2.00 ± 0.27 MJ/m3 at 600% elongation), and a rapid self-recovery (92 ± 1% toughness recovery within 20 min). Antifatigue behavior of the muscle-inspired hydrogel was observed upon successive tensile and compressive ...
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