Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.

Wojciech W. Krajewski,R. Collins,Lovisa Holmberg Schiavone,T. Alwyn Jones,Tobias Karlberg,Sherry L. Mowbray

Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes and provide opportunities for drug and herbicide design.

2008

Wojciech W. Krajewski
R. Collins
Lovisa Holmberg Schiavone
T. Alwyn Jones
Tobias Karlberg
Sherry L. Mowbray

Glutamine synthetase (GS) catalyzes the ligation of glutamate and ammonia to form glutamine, with concomitant hydrolysis of ATP. In mammals, the activity eliminates cytotoxic ammonia, at the same t ...

Keywords:

Enzyme
Glutamine
ATP hydrolysis
Biochemistry
Substrate (chemistry)
Molecular biology
Ligation
Nucleotide
Amino acid
Glutamine synthetase
Biology
DNA ligase
Glutamate receptor
Protein Data Bank (RCSB PDB)
Ammonia

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