Skeletal muscle strength in older adults. Angiotensinconverting enzyme (ACE) genotype affects: an UPDATE

Problem Statement : Previous studies have associated angiotensin-converting enzyme (ACE) with variability in the skeletal muscle baseline strength, though conclusions have been inconsistent across investigations. Approach: The purpose of this study was to review the most important studies that have been exanimate the possible association between ACE genotype and skeletal muscle baseline strength in elite male and female athletes involved in elderly populations. This research is needed because the possibility that the DD genotype may be associated with a greater proportion of fast twitch fibers could explain the influence of the ACE D allele upon strength/ power, particularly at high velocities, but this evidence remains equivocal in older people because more studies are necessary. Results: Thus, according to scientific evidence, changes in muscle strength with exercise training in older individuals may be dependent on ACE I/D genotype. Of note, the results provide a novel insight that these genetic variations may interact to determine muscle mass in older women specially. The determination of this predisposition in this population, highlighting the interest of study, for the prophylactic attitude on the factors and causes of aging (sarcopenia, osteoporosis, risk of falls, reduction of functional physical) go through this analysis.