8a as an anti-infection agent, 9-dihydro -4a-h- isothiazolo [5,4-b] quinoline-3,4-dione and related compounds

The present invention has an antimicrobial activity, provides compounds and salts of Formula I and Formula II. The present invention also provides useful new synthetic intermediates to compounds of Formula I and Formula II prepared. Variables Certain compounds of Formula I and Formula II disclosed herein are potent and / or selective inhibitors of bacterial replication. The present invention contain one or more compounds and one or more carriers of Formula I or Formula II, excipient or diluent, also provides an antimicrobial composition comprising a pharmaceutical composition. Such compositions may comprise in combination with the compounds and one or more other active agents of the formula I or may comprise a compound of formula II as the only active agent or Formula I or Formula II,. The present invention also provides a method for treating bacterial infections in eukaryotes.