A piece of the puzzle: Does bipolarity partly explain the high prevalence of treatment resistance in depression?

Abstract In this cross-sectional study we examined whether the prevalence of treatment resistant depression (TRD) can be partly attributed to level of bipolarity. We included data of 201 patients with either episodic depression or TRD, who received treatment for their depression at either an outpatient or 2nd opinion/daytime setting, within a specialised mental healthcare department in the Netherlands. Whether level of TRD, assessed by the ‘Dutch Measure for quantification of Treatment Resistance in Depression’, can be partly explained by level of bipolarity, assessed by ‘the Bipolarity Index’, was examined using linear regression. We found no direct association between level of TRD and level of bipolarity, nor did comorbid anxiety disorders obscure an existing association. In this study we found no evidence for overlooked bipolarity contributing to the high prevalence of TRD. If replicated, we could state that additional screening on bipolarity with an instrument such as the ‘Bipolarity Index’ in the specialised mental health care is unnecessary.