Animal Models of Nonalcoholic Fatty Liver Disease—A Starter’s Guide
2017
Nonalcoholic fatty liver disease (NAFLD) constitutes a major health concern with the increasing incidence of obesity and diabetes in many Western countries, reaching a prevalence of up to 30% in the general population. Animal models have played a vital role in elucidating the pathophysiological mechanisms of NAFLD and continue to do so. A myriad of different models exists, each with its advantages and disadvantages. This review presents a brief overview of these models with a particular focus on the basic mechanisms and physical, biochemical and histological phenotype. Both nutritional and chemically induced, as well as genetic models are examined, including models combining different approaches.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
82
References
138
Citations
NaN
KQI