Monoclonal antibodies to claudin-18 for the treatment of cancer

Antibody comprising a combination of heavy chains and light chains selected from the possibilities (i) to (ix): (i) the heavy chain comprises an amino acid sequence represented by SEQ ID 115 and the light chain comprises a sequence of amino acids represented by SEQ ID 122, (ii) the heavy chain comprises an amino acid sequence represented by SEQ ID 116 and the light chain comprises an amino acid sequence represented by SEQ ID 121, (iii) the heavy chain comprises a sequence amino acid represented by SEQ 117 ID and the light chain comprises an amino acid sequence represented by SEQ ID 123, (iv) the heavy chain comprises an amino acid sequence represented by SEQ ID 119 and the light chain comprises an amino acid sequence represented by SEQ ID 126, (v) the heavy chain comprises an amino acid sequence represented by SEQ ID 118 and light chain co mprende an amino acid sequence represented by SEQ ID NO: 125, (vi) the heavy chain comprises an amino acid sequence represented by SEQ ID NO: 120 and the light chain comprises an amino acid sequence represented by SEQ ID NO: 124, (vii) the chain heavy comprising an amino acid sequence represented by SEQ ID 120 and the light chain comprises an amino acid sequence represented by SEQ ID 127, (viii) the heavy chain comprises an amino acid sequence represented by SEQ ID 120 and the light chain comprises an amino acid sequence represented by SEQ ID 128, and (ix) the heavy chain comprises an amino acid sequence represented by SEQ ID 120 and the light chain comprises an amino acid sequence represented by SEQ ID 129.