Synthesis and antifungal activity of novel (1-aryl-2-heterocyclyl)ethylideneaminooxymethyl-substituted dioxolanes

Summary A novel series of (1-aryl-2-heterocyclyl)ethylideneaminooxymethyl-substituted dioxolanes IIIa-n were synthesized by condensation of substituted 1,3-dioxolan-4-ylmethyl p -toluenesulfonates 4 with l-(hydroxyimino)-1-aryl-2-heterocyclylethanes 5 . Compounds IIIa-n were found to have effective in vitro antifungal activity when evaluated against the pathogenic fungi Candida albicans , Aspergillus flavus and Fusarium solani with MIC (minimum inhibitory concentration) values of 10 μg·ml −1 for IIIa-1 and 5 μg·ml −1 for IIIm,n .