Reduced colonization and infection with miconazole-rifampicin modified central venous catheters: a randomized controlled clinical trial.

Results: A colonization of CVC was observed in six patients (5.1%) with a modified catheter and 38 patients (36.2%) with a standard catheter (P< 0.001). Five patients in the modified group (4.2%) and 18 in the standard group (17.1%) developed CRI (P 5 0.002). One assumed CR-BSI was detected in the standard group, with none in the modified group. No adverse effects related to the modified catheters and no antimicrobial resistance were observed. Conclusion: CVC supersaturated with miconazole and rifampicin were associated with a significantly lower risk for catheter colonization and catheter-related infections compared to standard catheters.