Mucosal innate immunity involves system "Probiotic lectins— Glycoconjugates" against microbial pathogens

The paper is overview of mainly own works. It is devoted to new insights of mucosal innate immunity involving lectin systems of probiotic bacteria (LSPB) recognizing glycoconjugates (GC). LSPB and probiotic phytolectins supporting human health (separately or in combinations with other antimicrobials and antipathogen factors) are important contributors to biotope distant protection against pathogens. Being metabolomebiotics, LSPB form reversible complexes to natural and artificial polymeric polyvalent GC that allows structure-functional building directed on duty network of cascades for predicted replies. Probiotic molecular-cellular network supersystem LSPB—GC serves as important synergistic one contributing to biotope human and microbiocenosis antipathogen resistance. This network influences mucosa pores, affine texture, and microecological redistribution in organism. Mucosal innate immunity LSPB-based concept and strategies against microbial and viral pathogens are proposed. Recognition activities of artificial polymeric GC and LSPB were compared. Prospects of antipathogen lectin-containing systems cofunctioning to antibodies, cytokines, enzymes, phytolectins and antibiotics are underlined.