Study on direct electrochemical behaviors and the electroanalytical method of matrine type alkaloids at glassy carbon electrode

Objective: To investigate the direct electrochemical behaviors of matrine(MT), oxymatrine(OMT), sophoridine(SR) and oxysophoridine(OSR) at a glassy carbon electrode in a physiological medium, and to determine the contents of commercial MT and SR pharmaceutical products were determined. Method: Their electrochemical behaviors and contents in 0.15 mol·L~(-1) NaCl aqueous solutions were obtained by cyclic voltammetry(CV) and square wave voltammetry(SWV) methods. Result: The electrochemical experimental results show that the two totally irreversible oxidation peaks for both MT and SR were observed, which potential values are 0.81 V and 0.92 V, and the electrode reaction processes were diffusion-controlled. But for both OMT and OSR, they have no oxidation peaks observed in the same condition as well. The linear range of the concentration of MT and SR and the contents in their products were obtained by SWV. Conclusion: The research results can be applied in determination of the contents of commercial MT and SR pharmaceutical products.