Association between Circulating Adiponectin and Interleukin-10 Levels in Android Obesity: Effects of Weight Loss

Objective: Adiponectin inhibits vascular inflammation and increases IL-10 mRNA expression in human macrophages. Thus, we investigated the possible relationship between plasma adiponectin and IL-10 levels and the effects of a diet-induced moderate weight loss on both cytokines. Patients and Study Design: Plasma adiponectin and IL-10 levels were analyzed in 64 android [body mass index (BMI), >28 kg/m2; waist to hip ratio (WHR), ≥0.86] and 20 gynoid [BMI, >28 kg/m2; WHR, <0.86] obese healthy women. Android obese women (49 ± 14 yr) had a mean BMI of 37.1 ± 5.3 kg/m2, similar to that of gynoid obese women (49 ± 11 yr; BMI, 33.4 ± 2.6 kg/m2). Twenty nonobese control women (46 ± 11 yr; BMI, 25.2 ± 2.2 kg/m2) were also studied. In 15 android obese women, measurements were repeated after a 12-wk diet period (1200 kcal/d). Results: Median adiponectin [5.2 (range, 3.3–7.8) vs. 12.1 (9.7–13.9) vs. 15.0 (12.6–18.2) μg/ml; P < 0.0001] and IL-10 [1.8 (1.2–3.3) vs. 3.5 (2.9–4.3) and vs. 4.1 (3.5–4.8) pg/ml; P < 0.0001] l...