Effect of imidazobenzoimidazole derivatives RU-353, RU-563, and lidocaine on cerebral circulation in rats.

A. P. Galenko-Yaroshevskii,A. Yu. Turovaya,A V. Uvarov,A. K. Prikhodko,M. N. Ivashev,A. V. Arl’t,V. A. Anisimova

Effect of imidazobenzoimidazole derivatives RU-353, RU-563, and lidocaine on cerebral circulation in rats.

2005

A. P. Galenko-Yaroshevskii
A. Yu. Turovaya
A V. Uvarov
A. K. Prikhodko
M. N. Ivashev
A. V. Arl’t
V. A. Anisimova

We demonstrated a dose-dependent inhibitory effect of novel imidazobenzoimidazole derivatives RU-353 and RU-563 on cerebral blood flow and systemic blood pressure in narcotized rats. The effects of RU-353 increased, while the effect of RU-563 decreased with increasing the dose.

Keywords:

Cerebral circulation
Cerebral perfusion pressure
Diabetes mellitus
Cerebral blood flow
Blood pressure
Biology
Lidocaine
Anesthesia
Endocrinology
systemic blood pressure
Internal medicine
inhibitory effect

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