COMPARISON OF FOUR NEW CONSENSUS CRITERIA AGAINST THE 1984 NINCDS-ARDRA CRITERIA FOR ALZHEIMER'S DISEASE

from 50 to 90 years old. This research was performed as part of a nationwide multicenter cohort called the CREDOS study. Twentynine subjects with SMI progressed to MCI or Alzheimer’s disease (AD) and the others (n1⁄4100) did not progress. We compared baseline demographics, blood chemistry and neuropsychological tests results between the two groups and assessed predictors and the hazard ratio (HR) for the progression. Results: Follow up durations were ranged from 0.5 to 4.7 years. Median time to event was 3.64 years. Age, apolipoprotein E4 (APOE4) incidence, baseline Mini-Mental State Examination (MMSE) score, memory scores, geriatric depression scale (GDS) scores, Boston naming test, Rey complex figure copy/ recall and stroop test scores were different between groups. Old age, abnormal recall scores in MMSE, existence of APOE4 allele and lower verbal memory delayed recall scores were the most potent predictors related with the progression and the sum of the 4 predictors explained better for the progression. Conclusions: Subjects with SMI who progressed to MCI/ AD showed different baseline characteristics and neuropsychological tests results. Old age, worse baseline memory scores and APOE4 allele existence were related with the progression of SMI and combining them might be better to predict the progression. How to better coordinate the relative contributions of each predictor deserves further investigation.