Male infertility in delay of sexual development

: The examination of 260 infertile males revealed that delay of sexual development (DSD) predisposes to male infertility. DSD is often characterized by autoimmune reactions pointing to DSD as one of the causes of autoimmune infertility. Spermatozoa in DSD have low viability. Hormonal changes in DSD in adult males did not significantly change from the group with normal sexual development. LH/testosterone and testosteron/estradiol differed significantly in DSD and hypogonadism. Calculation of these proportions may serve differential criteria of DSD and secondary hypogonadism.