Abstract 288: Positive Correlation of Intracoronary C-Reactive Protein With Platelet-Monocyte Complexes and Serum Amyloid A Protein Suggests Local Interrelationship Between Platelet Activation and Inflammation in the Acute Coronary Syndrome Patients.

Introduction: — Formation of platelet monocyte complexes (PMCs) may be a link between platelet activation and inflammation in the pathogenesis of acute coronary syndrome (ACS). It is not clear whether this relationship between PMC formation and inflammation is a systemic or a local phenomenon at the site of coronary plaque rupture. Hypothesis: — Relationship between PMC expression and inflammation is a local phenomenon in the coronary circulation of the ACS patients. Methods: — Samples were collected from coronary artery (CO) (distal to the lesion), using microcatheter, aorta (AO) and right atrium (RA) of 23 ACS patients (15 STEMI and 8 NSTEMI) and 7 stable angina patients . Plasma high sensitive C-reactive protein (CRP) and serum amyloid A protein (SAA) were estimated using BNII nephelometric method. PMCs (CD61,CD14 double positive cells) were identified by flow cytometry with FACS calibur machine (BD Biosciences). Results: — In the ACS group the median (IQR) CRP levels were 2.4 (0.8–5.9) mg/l, 3.0 (0.8–...