Impact of left ventricular remodeling and renal function on 24h-ECG recordings and cardiovascular outcome in elderly hypertensive patients.

Abstract Background The prognostic role of left ventricular remodeling and renal function in elderly hypertensive patients has been so far scarcely investigated. Aims We assessed the impact of left ventricular geometry and renal function on 24 h-Holter electrocardiogram (ECG) recordings and outcome in elderly hypertensive patients. Methods We enrolled 251 asymptomatic hypertensive elderly patients (> 65 year-old). Left ventricular remodeling was evaluated by 2-D echocardiogram. Lown's class, mean QTc and standard deviation of all normal R–R intervals (SDNN) were assessed by 24-h Holter-ECG recordings. Data on all-cause and cardiovascular mortality were collected for 2 years. Results Mean age was 76.2 ± 11.4 years. High Lown's classes were more frequently observed in the presence of left ventricular hypertrophy (LVH) (57.3% vs. 23.7%; p  Conclusions CKD and left ventricular remodeling predicted altered ventricular batmotropism. Diabetes, CKD, heart rate variability and QTc are important predictors of cardiovascular death in elderly hypertensive patients.