Reactive Oxygen Species Biology and Angiotensin Regulation of Human Vascular Tone - the Role of Angiotensin-Converting Enzyme Inhibitors and AT1 Receptor Blockers 53

The role of RAS in the development of hypertension and cardiovascular and renal diseases has been extensively studied and is well established. The impact of oxidative stress in vascular homeostasis has also been clearly defined. Many of the cellular effects of Ang II appear to be mediated by ROS generated by NAD(P)H oxidase. Here we provide an overview of ROS physiology in human vessels and in particular the interaction with RAS, as well as a discussion on mechanisms by which therapeutic interventions on RAS affect redox signaling in the vascular wall at a clinical level.