Applications and efficiencies of the first cat 63K DNA array
2018
The development of high throughput SNP genotyping technologies has improved the genetic dissection
of simple and complex traits in many species including cats. The properties of feline 62,897 SNPs
Illumina Infnium iSelect DNA array are described using a dataset of over 2,000 feline samples, the most
extensive to date, representing 41 cat breeds, a random bred population, and four wild felid species.
Accuracy and efciency of the array’s genotypes and its utility in performing population-based analyses
were evaluated. Average marker distance across the array was 37,741 Kb, and across the dataset, only
1% (625) of the markers exhibited poor genotyping and only 0.35% (221) showed Mendelian errors.
Marker polymorphism varied across cat breeds and the average minor allele frequency (MAF) of all
markers across domestic cats was 0.21. Population structure analysis confrmed a Western to Eastern
structural continuum of cat breeds. Genome-wide linkage disequilibrium ranged from 50–1,500 Kb for
domestic cats and 750 Kb for European wildcats (Felis silvestris silvestris). Array use in trait association
mapping was investigated under diferent modes of inheritance, selection and population sizes. The
efcient array design and cat genotype dataset continues to advance the understanding of cat breeds
and will support monogenic health studies across feline breeds and populations.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
83
References
29
Citations
NaN
KQI