Thyroid‐stimulating hormone and prolactin responses to thyrotropin‐releasing hormone in common migraine

Intravenous administration of 50 μg or 200 μg thyrotropin-releasing hormone (TRH) to men with common migraine elicited blunted prolactin (PRL) responses, when compared with healthy controls. The thyroid-stimulating hormone (TSH) response was enhanced after 50 μg TRH in the migraineurs, but not after 200 μg. The physiologic TSH dose-response relationship was abolished in migraine sufferers. The data may be interpreted in the light of dopaminergic and noradrenergic supersensitivity, for PRL and TSH, respectively. The TSH response in migraine differs from the one that occurs in depression.