Incubation of the coronary disease. Pediatric perspective.

: The atherosclerosis modifications at the vascular level are evidentiated early by diminishing the blood flow mediated vasodilatation, thickening of the arterial wall and the appearance since childhood of the aortic fibrose plates. Their evolution is determined mainly by the atherosclerotic dislipidemia. The maximum risk for atherosclerosis and coronary disease appears in the subjects with low birth weight which in the fetal period and childhood can develop epigenetic modifications in the tissues and organ development. The study proposes to collect the clinical, epidemiological, experimental and epigenetic data in an unified explanation of the induction mechanism of atherosclerosis.