Tetracycline derivatives: alternative effectors for Tet transregulators

-M2 in HeLa cell lines. We chose the seven clinically licensed and commercially available antibiotics: tc, dox, demeclocycline (demeclo), mi-nocycline (mino), chloro-tetracycline (Cl-tc), sancycline (san) and metacy-cline (meta), and additionally tigecy-cline (TGC), which belongs to the new group of glycylcyclines currently un-dergoing phase III clinical trials (www.clinicaltrials.gov). None of these deriv-atives, except for dox, have been tested with rtTA2