증례 : 원발성 담즙성 간경변증 2예

Two cases of primary biliary cirrhosis were diagnosed in a 40-year-old woman and a 61-year-old woman. One case complained of generalized pruritus, easy fatigability and indigestion, and the other case complained of easy fatigability and generalized weakness. They showed an increase in serum alkaline phosphatase and serum IgM, positive antimitochondrial antibody tests, histologic findings of portal expansion with fibrosis, a decreased number of interlobular bile ducts, focal periportal destruction and inflammatory cell infiltration. From the above two cases of primary biliary cirrhosis, we can conclude that we should suspect this disease in patients with pruritus and generalized weakness along with those who show obstructive types of liver function tests but do not display the obstructive lesions of extrahepatic bile ducts and larger intrahepatic bile ducts in U/S, CT or ERCP. It can help us to detect primary biliary cirrhosis that we reconsider the findings of liver biopsy in patients diagnosed as chronic B viral hepatitis or nonAnonB chronic hepatitis who complain of pruritus and show an increase in serum alkaline phosphatase, serum IgM, cholesterol and GGTP, along with positive antimitochondrial antibody test.