The first AMPA receptor negative modulators based on the tetrahydroquinazoline scaffold

A convenient approach to novel symmetric bispyrimidine diamines comprises S N Ar reactions of 4-fluoropyrimidine N -oxide with alkane-α,ω-diamines with subsequent reduction of N -oxide function. The obtained substances were tested in patch-clamp experiments for the influence on the kainateinduced currents in Purkinje neurons and showed negative modulating effect.