Functional biology of the a 2 d subunits of voltage-gated calcium channels

Cache domain: A protein domain identified by its homology to an extracellulardomain present in diverse bacterial chemotaxis receptors, including methyl-sensing receptors, that binds to small-molecule ligands such as amino acids.Rossmann fold: A structural protein domain often found in proteins that bindto nucleotides. The domain contains three parallel b strands linked by two ahelices.VWA domain: A structural domain, first identified in von Willebrand factor typeA itself, that is often involved in divalent-cation-dependent interactions withthe extracellular matrix.v-Conotoxin GVIA: A peptide toxin that irreversibly blocks N-type voltage-gated Ca