High selectivities in hydrogenation of halogenonitro-benzenes on Pd, Pt or raney nickel as catalysts

Publisher Summary Aromatic haloamines have a wide range of applications in the production of pharmaceuticals and agrochemical substances. The main route to these haloanilines involves reduction from the corresponding nitro compounds either with group VIII metal catalysts and hydrogen or with iron and hydrochloric acid. Most of the time, the reduction of halonitroaromatic to the corresponding amine is accompanied by simultaneous dehalogenation which lowers the yield and results in the formation of corrosive halogen acids. One of these families is included molecules in which the fluorine atom is contained within a CF 3 group bonded to the benzene core. This CF 3 group is insensitive to hydrogenation under operating conditions that are commonly used to reduce the NO 2 group in the nitrated precursor. The other family includes molecules containing at least one fluorine atom that is directly bonded to the aromatic core. Sometimes this aromatic core also contains chlorine atoms.