Polymorphisms in UGT1A gene family and irinotecan toxicity in patients with advanced colorectal cancer
2006
13049 Background: The irinotecan active metabolite, SN38, is inactivated through glucuronidation mainly by uridine diphosphate glucuronosyltransferase (UGT) 1A1. The (TA)7 allele of a polymorphism ...
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