Evaluation of a comprehensive risk factor index for acute coronary insufficiency

Earlier risk assessment for acute coronary insufficiency has been done on the basis of logistic function and multiple regression analysis. Such an approach does not take into account the pathophysiological relationships among risk factors and individual medical data. An alternative approach based on physiological modeling of myocardial oxygen demand and oxygen supply by the coronary circulation is presented. The ratio of the two is termed the adaption ratio. Sensitivity of this ratio to parameter perturbation is the risk for that particular parameter. The sum of the sensitivities for the various risk factors gives the risk index. A clinical study on 40 subjects in the age group 35 to 60 that is underway to assess the validity of the approach is described. >