Overcoming resistance to HER2 inhibitors through state-specific kinase binding

Chris J. Novotny,Sirkku Pollari,Jin H. Park,Mark A. Lemmon,Weijun Shen,Kevan M. Shokat

Overcoming resistance to HER2 inhibitors through state-specific kinase binding

2016

Chris J. Novotny
Sirkku Pollari
Jin H. Park
Mark A. Lemmon
Weijun Shen
Kevan M. Shokat

High-throughput screening identified a small-molecule compound that targets the active conformation of HER2 and is effective against growth-factor-mediated drug resistance.

Keywords:

Biochemistry
Kinase binding
Small molecule
Drug resistance
Molecular biology
High-throughput screening
Kinase
Biology
Binding site
High-Throughput Screening Assays
Cell growth

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