language-icon Old Web
English
Sign In

Valsartan refining method

2014 
The invention relates to a valsartan refining method. The concrete method comprises: employing an organic solvent to heat and dissolve valsartan, then adding neutral aluminium oxide or acidic aluminium oxide to perform adsorption processing, filtering off aluminium oxide, cooling the filtrate and crystallizing to obtain a solid for reducing the content of butyryl valsartan impurity and propionyl valsartan impurity in valsartan. The employed valsartan refining method is capable of reducing the content of butyryl valsartan impurity in valsartan to be 0.15% or less, and reducing the content of propionyl valsartan impurity in valsartan to be 0.10% or less, and has the refining yield of 85-95%.
    • Correction
    • Source
    • Cite
    • Save
    • Machine Reading By IdeaReader
    0
    References
    0
    Citations
    NaN
    KQI
    []