TINU syndrome, a case report and literature review

Tubulointerstitial nephritis and uveitis (TINU) syndrome is characterized by tubulointerstitial nephritis with sudden-onset of uveitis. Currently, only over 200 cases have been described in the literature. TINU syndrome might be underestimated due to lack of recognition and under-diagnosis. The pathogenesis of TINU syndrome remains unclear, it affects predominantly adolescents. We report a case of an acute renal insufficiency at a 42 years old woman whose exploration favors the diagnosis of a TINU syndrome; she was put under cortico-steroids with recovery of a normal renal function at 73 ml/ min/1.73 m 2 . Our message is to enquire specifically for episodes of uveitis in any patient presenting with unexplained acute interstitial nephritis and to keep in mind the diagnosis of TINU syndrome.