Effective delivery of a rationally designed intracellular peptide drug with gold nanoparticle–peptide hybrids

A novel gold nanoparticle–peptide hybrid strategy was developed to intracellularly deliver a potent PKCδ inhibitor peptide for the treatment of acute lung injury. The gold nanoparticle–peptide hybrids showed good stability with high uptake, and demonstrated in vitro and in vivo efficacy. Our formulation strategy shows great promise in intracellular delivery of peptides.