Annonaceous acetogenin high-efficiency part medicine-Ainuoning, preparation method and application thereof

2008 
The present invention discloses a highly effective annonaceous acetogenins part medicine-idarubicin hydrochloride for injection, the preparation method and application thereof. The principal ingredient comprises alpha, beta-unsaturation gamma-double tetrahydrofuran loop type annonaceous acetogenins compound with lactone structure -bullatacin and shikemoxin. The ingredients of the type account for 90 percent or above of the total mass number. The preparation method of the present invention causes little environmental pollution, is simple and can be easily implemented. Large scale production can be realized. The highly effective annonaceous acetogenins part medicine-idarubicin hydrochloride for injection presented by the invention can be used for preparing medicines for curing malignant tumor, HIV infect/AIDS, resembling rheumatism, psoriasis and lupus erythematosus autoimmune disease. In the preliminary clinical test of treating malignancy, and HIV infect / AIDS, the idarubicin hydrochloride for injection shows the predominance beyond compare of the Chinese and Western medicine medication.
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