Physicochemical properties affecting the potentialin vitro cytotoxicity of inorganic layered nanoparticles

Inorganic layered nanoparticles, also known as anionic nanoclays, have great potential as delivery carriers, since they could efficiently intercalate anionic molecules into the gallery spaces and release the intercalated molecules in a controlled manner. They also exhibit low toxicity compared to other widely studied inorganic nanoparticles for biological purposes. In this review, we summarize and describe physicochemical factors influencing the cytotoxicity of layered nanoparticles in cultured cell lines for providing information on their optimum characteristics with minimized adverse effects.