early outcome in the Edinburgh High-Risk Study Distinguishing characteristics of subjects with good and poor

Background ‘High-risk’studies ofschizophreniahavethepotentialto clarifythepathogenesisofschizophrenia.Here,resultsofextremeoutcomegroupsintheEdinburgh High-Risk Studyarepresented.Aims TocomparegroupsofgoodandpooroutcomefromtheEdinburghHigh-Risk Studyandclarify thenature oftheRiskStudyandclarifythenatureofthechangefromthestateofvulnerabilitytochangefromthestateof vulnerabilitytothatofdevelopingpsychosis.MMetethodhod Therecruitmentprocedureisdescribed.Goodandpooroutcomearedefined.Thesegroupsarecomparedintermsofgeneticliabilityandofbaselineterms ofgeneticliabilityand of baselineandchangeinneuropsychologyandneuroanatomy.RReesusulltsts Demographiccharacteristicsandgeneticliabilitydonotdifferbetweenthegroups.Thegoodoutcomegroupperformbetteratbaselineinsomeneuropsychologicaltests,butthereislittleneuroanatomicaldifference.Thepooroutcomegroupshowconsistentlyimpairedmemoryfunctionandatendency toreductionintemporallobesisizzee..Conclusions Ingeneticallypredisposedsubjects,thechangefromvulnerability to developingpsychosismayvulnerabilitytodevelopingpsychosismaybemarkedbyareducedsizeandimpairedfunctionofthetemporallobe.Declarationof interest ThisstudywasfinancedbytheMedicalResearchCouncil, whichsupports S.M.L. and R.C.