Large-scale synthesis of d-mannose 6-phosphate and other hexose 6-phosphates

Abstract The syntheses of d -mannose 6-phosphate ( 4 ), several d -mannopyranoside 6-phosphates, and methyl α- d -glucopyranoside 6-phosphate are de Compound 2 was obtained in 67% yield, from methyl 2,3,4,6-tetra- O -(trimethylsilyl)-α- d -mannopyranoside, by selective hydrolysis with a sa Butyl and hexadecyl α- d -mannopyranosides were prepared by glycosidation of the respective alcohols with tetra- O -benzoyl-α- d -mannopyrano