Advanced biocompatible, non-polymeric surface modified, iron oxide nanoparticles with application of optimal amount of gluconic acid and a composition for diagnosing and treating cancer comprising the same

PURPOSE: An iron oxide nano particle in which non-polymer bio molecules are introduced to a surface modifier and a cancer diagnosis and treatment composition including thereof are provided to improve delivery of oxide nano particles to target organ. CONSTITUTION: An iron oxide nano particle comprises iron oxide based core particles, a shell coated with soluble material which is selected from ATP, NAD, ADP, AMP and NADP, and gluconic acid combined in surface of the shell. The soluble are ATP. Fluorescent probes are additionally combined with surfaces of the nano particles. The fluorescence probes are chlorotoxin. A weight ratio of the gluconic acid to the iron oxide based core particle which is coated with ATP is 1:0.3-1:3. A diameter of the nano particle is 5-300 nano meters.