The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis

Marianne G. Pouwer,Suvi E. Heinonen,Margareta Behrendt,Anne-Christine Andréasson,Arianne van Koppen,Aswin L. Menke,Elsbet Pieterman,Anita M. van den Hoek,J. Wouter Jukema,Brendan Leighton,Ann-Cathrine Jönsson-Rylander,Hans M.G. Princen

The APOE∗3-Leiden Heterozygous Glucokinase Knockout Mouse as Novel Translational Disease Model for Type 2 Diabetes, Dyslipidemia, and Diabetic Atherosclerosis

2019

Marianne G. Pouwer
Suvi E. Heinonen
Margareta Behrendt
Anne-Christine Andréasson
Arianne van Koppen
Aswin L. Menke
Elsbet Pieterman
Anita M. van den Hoek
J. Wouter Jukema
Brendan Leighton
Ann-Cathrine Jönsson-Rylander
Hans M.G. Princen

Background. There is a lack of predictive preclinical animal models combining atherosclerosis and type 2 diabetes. APOE3-Leiden (E3L) mice are a well-established model for diet-induced hyperlipidemia and atherosclerosis, and glucokinase

Keywords:

Endocrinology
Hyperlipidemia
Diabetes mellitus
Disease
Apolipoprotein E
Type 2 diabetes
Internal medicine
Glucokinase
Knockout mouse
Medicine
Dyslipidemia
Metabolic syndrome
Triglyceride

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