Анализ полиморфизма генов интерлейкина-13 и системы детоксикации ксенобиотиков у детей с аллергопатологией

The paper provides results of interleukin-13 genotyping with respect to three polymor-phous locuses (-1512А>С, -1112С>Т and +2044G>A) as well as studies on zero-polymorphism of genes M1 and T1 glutathione-S-transferase in children living in Vladivostok diagnosed with allergic diseases (73 patients) and allergic pathology-free (27 patients). As reported, there are no evidences that the “zero” genotypes GSTM1 and GSTT1 cause allergic diseases. There has been considerable prevalence of heterozygous carrier state of 1112С/Т among the patients (58 % against 22.2 % in control). The heterozygous states were reliably more often observed simultaneously by 2 or 3 polymor-phous locuses (48.4 % against 18.5 % in control) in children with clinical manifestations of the allergic diseases. The interleukin-13 genotyping by three polymorphous locuses can be recommended for applying as additional criterion of risk groups for the allergic diseases.