Heparanase: roles in cell survival, extracellular matrix remodelling and the development of kidney disease

Heparanase is an endoglycosidase that regulates numerous cell functions and is able to degrade the extracellular matrix component heparan sulfate, which has a key role in maintaining the integrity of the glomerular filtration barrier. In this Review, Rabelink and colleagues describe the biological regulation and functions of heparanase, including the role of this enzyme in the development of kidney disease.