[Expression of A-kinase anchor protein 95, cyclin E2, and connexin 43 in lung cancer tissue, clinical significance of their expression, and their expression correlation].

Objective To study the expression of A-kinase anchor protein 95 (AKAP95),cyclin E2,and connexin 43 (Cx43) in lung cancer tissue,the clinical significance of their expression,and the expression correlation among the three proteins.Methods Fifty-one samples of lung cancer tissue were examined by immunohistochemistry to measure the expression of AKAP95,cyclin E2,and Cx43.Results The positive rate of AKAP95 expression in lung cancer tissue was significantly higher than that in paracancerous tissue (82.35％ vs 33.33％,P＜0.05); AKAP95 expression was associated with the cell differentiation and histopathological type of lung cancer (P＜0.05).The positive rate of cyclin E2 expression in lung cancer tissue was significantly higher than that in paracancerous tissue (43.14％ vs 13.33％,P＜0.05); cyclin E2 expression was associated with the lymph node metastasis and histopathological type of lung cancer (P＜0.05).The positive rate of Cx43 expression in lung cancer tissue was lower than that in paracancerous tissue (60.78％ vs 80.00％); Cx43 expression was associated with the cell differentiation,lymph node metastasis,and histopathological type of lung cancer (P＜0.05).There was correlation between each two of AKAP95 expression,cyclin E2 expression,and Cx43 expression in lung caner tissue.Conclusion High expression of AKAP95 and cyclin E2 plays an important role in the occurrence and development of lung cancer.AKAP95 expression is associated with the cell differentiation and histopathological type of lung cancer,and cyclin E2 expression is associated with lymph node metastasis and histopathological type.There is correlation between each two of AKAP95 expression,cyclin E2 expression,and Cx43 expression in lung caner tissue. Key words: Lung cancer;  AKAP95;  Cyclin E2;  Cx43