Are there effects of lunar cycle on pediatric febrile seizure?: A single-center retrospective study (2005–2018)

Abstract Background Several studies have reported an association between seizure and the lunar cycle; however, results are conflicting. Thus, we investigated whether emergency department (ED) visits due to febrile seizure (FS) or FS plus were affected by lunar cycle. Methods We reviewed the medical records of patients who were admitted to the ED with a main diagnosis of FS or FS plus from January 1, 2005 to August 31, 2018 (13 years 8 months), a period of 4991 days with 169 lunar cycles. During that period, we collected weather data such as mean temperature, average atmospheric pressure (AP), and humidity according to lunar phase (new moon, first quarter, full moon, and third or last quarter). Results A total of 1979 patients were identified. We found male predominant with a mean age of 2.62 ± 2.09 years. Acute pharyngotonsillitis was the most common cause of fever, generalized tonic-clonic seizure was the most common type of seizure, and the mean peak body temperature was 38.77 ± 0.81 °C. The lunar cycle did not affect the onset or frequency of FS after adjustment; however, several factors, including season, O 3 and NO 2 concentrations, and holidays, were associated with FS. Conclusion We did not find an association between lunar cycle and FS or FS plus. However, several factors, including season, O 3 , NO 2 , and holidays were associated with FS or FS plus.