Toll Like Receptor 2 promoter -196 to -174 deletion affects CD4 levels along HIV infection progression.

TLR2 plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter Insertion/Deletion polymorphism with contradictory data about its role in HIV-1 infection. We analyzed rs111200466 in HIV-1 disease progression and showed a correlation with a faster progression to the CD4+ 350cells/μL, Cox P=0.36). Our data suggests rs111200466 as a prognosis factor for HIV-1 disease progression.