Klinische und biochemische Aspekte der Hypertriglyceridämie bei Leberkrankheiten

Summary In evaluating the mechanism of hypertriglyceridemia in hepatic disease serum triglyceride levels were correlated with a number of li ver function tests. The correlation between serum triglycerides, serum bilirubin and the presence or absence of lipoprotein X were significant on the 0,1 0/0 level. There existed no significant correlation between serum triglycerides and prothrombin time. The results suggest that hypertriglyceridemia in hepatic disease may be a conse­ quence of biliary retention rather than of parenchym al damage. In the plasma of patients with hypertriglyceridemia secondary to liver disease an abnormally large (300-700 A), triglyceride rich, low density lipoprotein (d 1.019-1.063 g/ml) designated s~-lipoprotein was identified, isolated and characterized. The s~-LP differs significantly in its percent composition and protein moiety from the unique lipoprotein X (LP-X) and also from normal s-lipoproteins. Furthermore, some evidence is provided suggesting that the in­ crease of 132-LPin serum is due to a markedly diminished hepatic lipase activity.