Role of mevalonic acid pathway in the regulation of cell growth

Mevalonic acid (MVA) pathway plays a key role in regulation of cell growth, MVA and derivatives effect the action of Ras protein, growth factor and receptor, intrac ellular signal transduction and cell growth through isopentenyl and N linked glycosylation modification on protein. Another mechanism of MVA pathway in regulation of cell growth is that affect production of vasoactive matter. Activity of 3 hydroxy 3 methylgutaryl coenzyme A (HMG-CoA) reductase, limiting enzyme involved production of MVA, is inhibited by MVA pathway derivatives. HMG CoA reductase inhibitors could inhibit cell growth and proliferation through inhibiting production of MVA and derivatives.