In vivo Raman spectroscopy for breast cancer : diagnosis in animal model
2008
Raman spectroscopy has been well established as a powerful method for studying biological tissues and
diagnosing diseases. In this study we have developed a breast cancer animal model and collected in
vivo Raman spectra of mammary glands of 27 Sprague-Dawley female rats treated with DMBA and 5
non-treated used as control group. A dispersive Raman spectrometer with a @785 nm laser excitation
coupled a fiber optic probe and a CCD detector was used to obtain the spectra. The obtained in vivo
transcutaneous Raman spectra have shown important differences between normal and abnormal tissues
when acquired from one side to the other side of the lesion.
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